A NAD+ pen, in the sense used on this site, is a pen-format cartridge holding NAD+ (Nicotinamide Adenine Dinucleotide) already in solution. A click mechanism advances a threaded rod by a fixed increment, so each click displaces the same known volume from the cartridge. The format exists to give a laboratory a repeatable volume of a compound that is unstable once dissolved, without a reconstitution step at the bench.
Format is the main reason NAD+ pens exist. NAD+ in solution is sensitive to pH, temperature and light, and most NAD+ sold for research ships as a freeze-dried powder that has to be reconstituted before it can be used at the bench, which is where the largest handling error is usually introduced. A pre-filled cartridge is buffered and sealed at the facility, so the composition on the batch certificate is the composition that is dispensed.
NAD+ reaches the research market in three broad formats. First, lyophilised powder in a vial, the most common format, which needs bacteriostatic water and a reconstitution step. Second, pre-filled pen-format cartridges from specialist suppliers, already in solution and shipped cold. Third, oral precursor products (NMN, NR, liposomal and sublingual formats), which contain a precursor rather than the coenzyme itself and belong to a separate body of literature. This guide covers the second format.
The Celyfe NAD+ Precision Pen sits in the second category. The cartridge holds 500mg of NAD+ in 3ml of solution, a supplied concentration of 166.7mg/ml, with a phosphatidylcholine complex and trans-resveratrol in the vehicle. The pen dispenses 0.01ml per click, which is 1.667mg of NAD+, across 300 calibrated clicks. It is supplied strictly for in-vitro laboratory research, with availability in the UK and US via celyfe.com.
Documentation checks before ordering any NAD+ pen: cold-chain handling (NAD+ in solution is temperature-sensitive and is normally shipped and stored refrigerated), a published certificate of analysis for the batch, a clear mass per click and per cartridge rather than a vague cartridge total, and a seller registered in the buyer's market - orders shipped from outside the US or EU/UK can face customs scrutiny.
A note on naming: Celyfe (celyfe.com, CELYFE ENTERPRISE LTD, London) is a company registered in England and Wales and is not affiliated with Cellife Health Care, an Australian brand that sells oral NAD+ tablets. The two are frequently confused; only Celyfe makes the NAD+ Precision Pen.
Celyfe NAD+ pens are research formats, not medicines or supplements, and are not intended to diagnose, treat, cure, or prevent any disease. They are supplied strictly for in-vitro laboratory research, and nothing in this article is guidance on use in humans or animals.
This article is an editorial piece and is provided for informational purposes only. It is not medical advice. Celyfe pens are supplied strictly for in-vitro laboratory research.