Scientifically reviewed by Dr Stephan Hansberg
How the Celyfe pen works
The mechanics of the Celyfe precision pen: the click ratchet and threaded rod, 0.01ml per click, priming, needle compatibility, and why it is a volumetric device, not a dosing device.
Key takeaways
- •Each Celyfe pen uses a click ratchet mechanism turning a threaded rod to advance a fixed volume with every click.
- •One click dispenses 0.01ml, and a 3ml cartridge provides exactly 300 clicks.
- •Priming the pen before first use ensures the needle is filled and clicks correspond accurately to dispensed volume.
- •The pen is compatible with standard pen needles, which are not included and are sourced separately.
- •The pen is a volumetric measuring device for research use, not a medical dosing device, and it carries no dosing instructions.
The click ratchet mechanism
Inside the pen body, a click ratchet mechanism connects the dial or plunger to a threaded rod that sits behind the cartridge's internal seal. Each click of the mechanism advances the rod by a fixed, mechanically defined increment, pushing the seal forward by exactly enough to displace 0.01ml of the cartridge's contents through the needle port. Because the advance per click is fixed by the mechanism rather than estimated by the user, the volume dispensed per click is consistent throughout the life of the cartridge.
0.01ml per click, 300 clicks per cartridge
Each Celyfe cartridge holds 3ml of pre-filled, pre-mixed solution. At 0.01ml displaced per click, a full cartridge corresponds to exactly 300 clicks from first use to empty, assuming the pen has already been correctly primed. This fixed relationship between clicks and volume is what allows the pen to function as a precise volumetric measuring instrument for laboratory use.
Priming
Priming refers to clicking the pen with a needle attached, before first use, until a small amount of liquid is visible at the needle tip. This step clears any air that may be present in the needle and the connection point between the needle and cartridge, ensuring that the first clicks used for actual measurement correspond accurately to dispensed liquid volume rather than partly to air displacement.
Needle compatibility
The Celyfe pen is designed to be compatible with standard pen needles, of the kind widely used with other pen-style dispensing devices. Needles are not included with the pen or cartridge and should be sourced separately from a supplier of laboratory or medical consumables.
A volumetric device, not a dosing device
It is worth being precise about what the pen is: a mechanical instrument that dispenses a fixed, known volume of liquid per click, for use in a laboratory or research context. It is not a medical dosing device, it is not calibrated or licensed for administration to a human or animal body, and Celyfe does not provide dosing instructions, protocols or guidance of any kind for such use. Researchers are responsible for their own institutional and laboratory protocols when handling any research compound.
Research use only
The mechanism described in this guide exists to give researchers precise, repeatable volume measurement when handling pre-filled research cartridges. Nothing here describes or implies administration to a human or animal body.
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